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Lipid peroxidation induced by cyclophosphamide
M J Berrigan1, R F Struck, H L Gurtoo
1Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo 14263.
Cancer Biochemistry Biophysics
|September 1, 1987
Abstract:
Intraperitoneal administration of a single dose of cyclophosphamide (CP) to rats was found to produce hepatic glutathione depletion and to enhance NADPH-mediated lipid peroxidation in the 15,000 x g supernatant fraction of the liver. These effects were associated with CP in a dose- and a time-dependent manner. The data suggest that the glutathione depletion is, at least in part, responsible for the enhancement in lipid peroxidation induced by CP.