The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) program: study protocol for a...

Area of Science:

• Public Health
• Preventive Medicine
• Clinical Trials

Background:

• Community-based diabetes prevention programs show varied effectiveness.
• A stepwise approach combining lifestyle interventions, metformin, and financial incentives has not been widely studied in practice.
• The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) trial addresses this gap.

Purpose of the Study:

• To compare the effectiveness of a community-based stepwise diabetes prevention program with financial incentives against standard care.
• To reduce the risk of type 2 diabetes in overweight or obese individuals with pre-diabetes over three years.

Main Methods:

• An open-label, 1:1 randomized controlled trial involving 846 adults with pre-diabetes in Singapore.
• Intervention includes group sessions, physical activity and nutrition recommendations, text message tips, metformin (for high-risk individuals), and a rewards program.
• Primary endpoint: proportion of participants developing diabetes at 3 years. Secondary endpoints: changes in glucose levels, HbA1c, weight, BMI, physical activity, and diet.

Main Results:

• This section is not available in the provided abstract.

Conclusions:

• The Pre-DICTED trial will offer evidence on the effectiveness and feasibility of this comprehensive diabetes prevention strategy.
• Findings will inform future cost-effectiveness analyses and guide policymakers on potential nationwide implementation.
• The study aims to provide valuable data for public health strategies targeting pre-diabetes management.