[Differential Diagnosis of Three Commonest Deletion β-Thalassemia in Chinese]

To analyze the hematological characteristics of Chinese ^Gγ⁺(^Aγδβ)⁰-thalassemia，SEA-HPFH and Taiwan type β-thalassemia.

Hemoglobin electrophoresis and blood routine test were used to analyze the hematological indexes of all peripheral blood samples，PCR-Flow fluorescent hybridization and Gap-PCR were used to detect the globin gene mutations and the data were analyzed statistically.

The 3 types of deletion β- Thalassemia patients were showed as hypochromic small cell anemia. The MCH and MCV values of Taiwan type β-thalassemia patients were the lowest. The results of hemoglobin electrophoresis showed that the increasing of HbF was found in all of the 3 types. Except for the decreasing of Hb A2 in Chinese ^Gγ⁺(^Aγδβ)⁰-thalassemia，the levels of Hb A2 in the other two deletion β-thalassemia patients were significantly increased. Except for Hb, there were significant differences in MCV, MCH, Hb A2 and HbF between Chinese ^Gγ⁺(^Aγδβ)⁰-thalassemia and SEA-HPFH(P<0.001).

Through analyze the hematological characteristics, it can be provide that the guidance for the differential diagnosis and genetic consultation of the three commonest deletion β-thalassemia in Chinese.