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Updated: Oct 25, 2025
09:46
Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
Published on: August 26, 2018
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Redox Active Cerium Oxide Nanoparticles: Current Status and Burning Issues
Megan S Lord1, Jean Francois Berret2, Sanjay Singh3
1Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, New South Wales, 2052, Australia.
Small (Weinheim an Der Bergstrasse, Germany)
|August 7, 2021
Summary
Cerium oxide nanoparticles (nanoceria) show promise as antioxidants for treating diseases. Further research is needed to fully understand their complex redox behavior and biological interactions.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Cerium oxide nanoparticles (nanoceria) possess unique redox and oxygen buffering properties.
- Nanoceria exhibit antioxidant properties, showing potential for treating diseases linked to reactive oxygen species (ROS).
- The precise mechanism of ROS scavenging by nanoceria remains unclear, with conflicting reports on their pro-oxidant and antioxidant activities.
Purpose of the Study:
- To critically review the current research on nanoceria applications for ROS-related diseases.
- To analyze proposed mechanisms of action and the influence of surface coatings on nanoceria's redox activity.
- To identify key challenges and suggest future research directions for understanding nanoceria's biological behavior.
Main Methods:
- Literature review and critical analysis of existing research on nanoceria.
- Examination of studies investigating nanoceria's antioxidant and pro-oxidant effects.
- Analysis of factors influencing nanoceria's behavior in biological environments, including surface modifications.
Main Results:
- Nanoceria's redox mimetic antioxidant properties are recognized for potential therapeutic applications.
- Controversy exists regarding nanoceria's dual pro-oxidant and antioxidant activities, necessitating further investigation.
- Surface coatings significantly impact nanoceria's redox behavior and biological efficacy.
Conclusions:
- Understanding nanoceria's behavior in biological systems is crucial for their therapeutic development.
- Further research is essential to elucidate the mechanisms behind nanoceria's redox activity.
- Future studies should focus on resolving the controversies surrounding nanoceria's pro-oxidant/antioxidant balance and optimizing surface modifications for targeted applications.
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