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Published on: May 17, 2016
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Rodent models of hypertension
Hamdi A Jama1,2, Rikeish R Muralitharan1,3, Chudan Xu1
1Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University, Melbourne, Australia.
British Journal of Pharmacology
|August 7, 2021
Summary
Rodent models are crucial for studying hypertension, a major cardiovascular disease risk factor. This review examines rodent models, detailing how various systems influence blood pressure and exploring pulmonary and pregnancy-related hypertension.
Area of Science:
- Cardiovascular Research
- Preclinical Models
- Hypertension Pathophysiology
Background:
- Hypertension is a primary risk factor for cardiovascular disease, posing significant research challenges due to its systemic and multifactorial nature.
- Rodent models are essential tools for investigating the genetic, cellular, and molecular mechanisms of hypertension and for testing novel antihypertensive therapies.
Purpose of the Study:
- To provide a comprehensive review of rodent models for hypertension research.
- To analyze the strengths and weaknesses of these models using a systems approach.
- To highlight the influence of key organs and systems on blood pressure regulation within these models.
Main Methods:
- Systematic review of existing literature on rodent models of hypertension.
- Analysis of how target organs (kidneys, vasculature) and systems (sympathetic nervous system, immune system, gut microbiota) impact blood pressure in different models.
- Inclusion of less commonly studied hypertensive conditions like pulmonary hypertension and pregnancy-related disorders.
Main Results:
- Rodent models offer valuable insights into hypertension but possess distinct strengths and limitations.
- The kidneys, vasculature, sympathetic nervous system, immune system, and gut microbiota play critical roles in blood pressure regulation across various models.
- Specific models effectively recapitulate different facets of human hypertension, aiding mechanistic and therapeutic research.
Conclusions:
- Rodent models are indispensable for advancing our understanding of hypertension.
- A systems-level analysis is crucial for appreciating the complexity of hypertension in preclinical models.
- This review serves as a vital resource for researchers studying hypertension, including specialized forms.
