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Self Assembled Cages with Mechanically Interlocked Cucurbiturils.

Kimberly G Brady¹, Bingqing Liu², Xiaopeng Li²

¹Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.

Supramolecular Chemistry

|August 9, 2021

Summary

This summary is machine-generated.

Researchers developed new molecular assemblies using viologen-based ligands and iron. These assemblies, including tetrahedral and cubic structures, can mechanically interlock with cyclodextrrin (CB[7]) units, showing potential for advanced supramolecular chemistry applications.

Keywords:

Cucurbit[n]uril mechanical interlocked compounds metal organic polyhedra self-assembly

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Area of Science:

Supramolecular Chemistry
Coordination Chemistry
Materials Science

Background:

Viologen-based ligands are crucial for constructing self-assembled molecular architectures.
Mechanical interlocking of host-guest complexes offers advanced functionalities in supramolecular chemistry.
Hydrolytic instability of imine linkages limits applications in aqueous environments.

Purpose of the Study:

To design and synthesize novel viologen-containing ligands for self-assembly.
To investigate the formation of tetrahedral and cubic metal-organic polyhedra (MOPs).
To explore the mechanical interlocking of cyclodextrins within these assemblies.

Main Methods:

Synthesis of bis(aniline) ligands with a central viologen binding domain.
Subcomponent self-assembly with metal ions (Fe(II)) and aldehydes or pre-complexed cyclodextrins (CB[7]).
Characterization using NMR spectroscopy, DOSY, and mass spectrometry.

Main Results:

Formation of tetrahedral and cubic assemblies using imine-based and bipyridine-based ligands.
Successful mechanical interlocking of cyclodextrins (CB[7]) within the assemblies, with varying degrees of interlocking.
Demonstration of hydrolytic instability in imine-linked assemblies and improved stability with bipyridine ligands.

Conclusions:

Viologen-based ligands enable the construction of diverse self-assembled architectures.
The system allows for tunable mechanical interlocking of cyclodextrins within MOPs.
Redesigning ligands with water-stable groups enhances the robustness of the molecular assemblies.