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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
34
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Related Experiment Video

Updated: Oct 25, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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Cyclodextrin-based Pickering emulsions: functional properties and drug delivery applications.

Mario Jug1, Bo Kyeong Yoon2, Joshua A Jackman2

  • 1Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, Zagreb, Croatia.

Journal of Inclusion Phenomena and Macrocyclic Chemistry
|August 9, 2021
PubMed
Summary

Cyclodextrins (CDs) stabilize Pickering emulsions without surfactants, offering enhanced stability and tolerability. These biocompatible compounds show promise in drug delivery, cosmetics, and nutraceuticals.

Keywords:
AntifungalsCyclodextrinDrug deliveryLipidsPickering emulsionStability

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Area of Science:

  • Interfacial Science
  • Colloid and Surface Chemistry
  • Materials Science

Background:

  • Cyclodextrins (CDs) are biocompatible cyclic oligosaccharides with unique interfacial properties.
  • CDs exhibit low intrinsic surface activity but can stabilize emulsions via inclusion complexation.
  • Surfactant-free Pickering emulsions stabilized by CDs offer advantages over conventional emulsions.

Purpose of the Study:

  • To review the molecular mechanisms of CD-stabilized Pickering emulsions.
  • To discuss preparation methods, lipid encapsulation, and stability of CD-based Pickering emulsions.
  • To highlight applications in drug delivery, cosmetics, nutraceuticals, and translational medicine.

Main Methods:

  • Critical review of recent literature on CD-stabilized Pickering emulsions.
  • Analysis of molecular mechanisms of emulsion stabilization.
  • Discussion of preparation techniques and characterization methods.

Main Results:

  • CDs stabilize Pickering emulsions by complexing oil-phase components at the interface.
  • CD-based Pickering emulsions demonstrate enhanced physical stability and tolerability.
  • Rheological, textural, and functional properties are detailed for various applications.

Conclusions:

  • CD-stabilized Pickering emulsions represent a promising surfactant-free formulation strategy.
  • Applications span drug delivery, cosmetics, nutraceuticals, and antimicrobial therapies.
  • Future directions include leveraging molecular encapsulation for antiviral and antibacterial applications.