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Research Progress on the Correlation Between Epigenetics and Schizophrenia.

Qing Chen¹, Dan Li¹, Weifeng Jin¹

¹Clinical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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|August 9, 2021

Summary

Epigenetic modulations like DNA methylation and non-coding RNAs are linked to schizophrenia pathogenesis. These epigenetic changes offer potential for diagnosing schizophrenia and guiding personalized treatments.

Keywords:

DNA methylation epigenetics histone modification non-coding RNA schizophrenia

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Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Schizophrenia incidence is increasing, leading to significant social and health impairments.
Accurate diagnosis of schizophrenia remains challenging, with both genetic and environmental factors implicated.
Epigenetic mechanisms, influenced by environmental factors, are increasingly recognized for their role in gene expression and disease development.

Purpose of the Study:

To review current understanding of epigenetic modulations in schizophrenia pathogenesis.
To highlight the potential of epigenetic alterations as biomarkers for schizophrenia diagnosis and treatment.

Main Methods:

Review of existing literature on epigenetic modifications in schizophrenia.
Analysis of findings related to DNA methylation, non-coding RNAs, and histone modification.

Main Results:

DNA hypermethylation and hypomethylation are associated with schizophrenia in brain and blood samples.
Alterations in non-coding RNAs (microRNAs, long non-coding RNAs) show diagnostic potential and may predict treatment response.
The role of histone modification in schizophrenia pathogenesis is currently unclear.

Conclusions:

Epigenetic modulations, including DNA methylation and ncRNA regulation, are crucial in schizophrenia pathogenesis.
Assessing epigenetic alterations could aid in schizophrenia diagnosis and the development of individualized treatment strategies.