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Immunohistochemistry for (Pro)renin Receptor in Humans
Satoshi Morimoto1, Noriko Morishima1, Daisuke Watanabe1
1Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
International Journal of Endocrinology
|August 9, 2021
Summary
The (pro)renin receptor protein is found in nearly all human organs, including the brain and adrenal glands. Its varied expression suggests diverse physiological functions across different tissues.
Area of Science:
- Physiology
- Molecular Biology
- Cell Biology
Background:
- The (pro)renin receptor is a key protein involved in cellular signaling pathways.
- It also functions as an accessory protein for the vacuolar H+-ATPase, impacting hormone secretion.
- While its mRNA is widespread, the protein's tissue distribution remained largely unknown.
Purpose of the Study:
- To systematically map the protein expression of the (pro)renin receptor across various human organs.
- To investigate the cellular localization of (pro)renin receptor protein.
Main Methods:
- Systemic immunohistochemical analysis was performed on human autopsy tissues.
- Examination included a comprehensive range of whole-body organs.
Main Results:
- (Pro)renin receptor protein was detected in the cytoplasm of cells in almost all examined human organs.
- Specific expression was noted in the thyroid, liver, pancreas, adrenal glands, kidneys, heart, skeletal muscle, and throughout the brain.
- In the pituitary gland, (pro)renin receptor co-localized with all anterior pituitary hormone-producing cells.
Conclusions:
- The (pro)renin receptor protein is ubiquitously expressed throughout the human body.
- Observed cell-specific expression patterns indicate diverse physiological roles in different organs.
- This widespread distribution supports the receptor's involvement in numerous bodily functions.
