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Manic Episode Induced by Lamotrigine in Rapid Cycling Bipolar Disorder
Ana Lúcia Ramos1, Henrique Salgado1, Miguel Bragança1
1Psychiatry, University Hospital Center of Sao Joao, Oporto, PRT.
Abstract:
Bipolar disorder is characterized by persistent and/or recurrent mood changes between depressive and manic poles. Rapid cycling is a frequent, although underrecognized, condition in bipolar disorder, and it is known to worsen the prognosis of the disease. With regard to the treatment of bipolar depression, there is a shortage of evidence-supported treatment choices, and the literature on the subject includes few references to cases of manic switch induced by lamotrigine. The authors describe a case of a rapid cycling bipolar patient who presented manic symptoms after initiating treatment with lamotrigine.
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