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Related Experiment Video

Updated: Oct 25, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Syphilitic interstitial keratitis treated with topical tacrolimus.

Jacob Martin¹, Laura Kopplin², Deborah Costakos¹

¹Medical College of Wisconsin, 925 N 87th St, Milwaukee, WI, 53226, USA.

American Journal of Ophthalmology Case Reports

|August 9, 2021

Summary

Topical tacrolimus offers a new treatment for syphilitic interstitial keratitis in children. This approach is effective for patients experiencing steroid-induced high intraocular pressure, preventing disease recurrence.

Keywords:

Interstitial keratitis Steroid response Syphilis Tacrolimus

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Last Updated: Oct 25, 2025

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Area of Science:

Ophthalmology
Infectious Diseases
Pediatrics

Background:

Syphilitic interstitial keratitis (SIK) is an inflammatory eye condition often associated with congenital syphilis.
Standard treatment involves topical steroids, which can lead to significant side effects like elevated intraocular pressure (IOP).

Observation:

A pediatric patient with congenital syphilis presented with bilateral SIK.
Initial management with topical steroids resulted in steroid-induced ocular hypertension and recurrent keratitis.
Topical tacrolimus was administered following a recurrence in the right eye.

Findings:

The patient achieved sustained remission of SIK with topical tacrolimus.
Normal intraocular pressure was maintained throughout the treatment period.
The patient remained recurrence-free for nearly three years.

Implications:

Topical tacrolimus is a promising alternative for managing SIK, especially in pediatric cases.
This treatment is particularly valuable for patients intolerant to steroids due to elevated IOP.
Tacrolimus offers a steroid-sparing option for chronic or recurrent SIK.