Related Experiment Video
Updated: Jun 12, 2025

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale
Published on: April 19, 2021
Open-source compact time-domain hydrogen (1H) NMR System for Field Deployment
Winford Janvrin1, Jacob Martin1,2, Daniel Hancock1,2
1University of South Carolina, Department of Mechanical Engineering, Columbia SC, United States.
Abstract:
This paper presents a compact, low-cost time-domain nuclear magnetic resonance (TD-NMR) system based on a 0.5 T permanent magnet designed for in-situ H measurements. Unlike conventional high-field nuclear magnetic resonance (NMR) spectrometers, this system emphasizes relaxation times rather than chemical shifts, enabling material property analysis without large magnets or complex spectral processing. The hardware employs an off-the-shelf data acquisition and control system along with a custom PCB for signal conditioning, ensuring straightforward deployment and reduced costs. The system's core sequence is a Carr-Purcell-Meiboom-Gill pulse train, chosen for efficient relaxation measurements under varying magnetic susceptibilities. By focusing on relaxation measurements, this approach bypasses complexities of high-resolution spectroscopy, enhances signal-to-noise in low-field conditions, and enables robust characterization across challenging environmental settings. We validate the system using aqueous Copper(II) sulfate solutions, correlating T values with copper concentrations to simulate environmental heavy metal contamination monitoring. Prior work has demonstrated versatility in fuel property analysis and environmental sensing, confirming broad applicability for this portable platform. While packaging and integration with ancillary equipment (e.g., flow-through systems) are not covered, the platform serves as a versatile foundation for specialized deployments. Its open-source design and affordability aim to democratize NMR technology and extending its utility beyond conventional laboratory environments. This accessible configuration fosters widespread educational and professional use.
More Related Videos
14:55Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
11:47Concentration of Metabolites from Low-density Planktonic Communities for Environmental Metabolomics using Nuclear Magnetic Resonance Spectroscopy
Published on: April 7, 2012
Related Concept Videos
¹H NMR of Labile Protons: Temporal Resolution
The –OH proton in alcohols typically appears in the range of δ 2 to 5 ppm but can vary depending on the specific...
¹H NMR of Labile Protons: Deuterium (²H) Substitution
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution
2D NMR: Overview of Heteronuclear Correlation Techniques
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)