Protective effect of hydrogen sulfide on the kidney (Review)

Hydrogen sulfide (H₂S) is a physiologically important gas transmitter that serves various biological functions in the body, in a manner similar to that of carbon monoxide and nitric oxide. Cystathionine‑β‑synthase, cystathionine‑γ‑lyase and cysteine transaminase/3‑mercaptopyruvate sulphotransferase are important enzymes involved H₂S production in vivo, and the mitochondria are the primary sites of metabolism. It has been reported that H₂S serves an important physiological role in the kidney. Under disease conditions, such as ischemia‑reperfusion injury, drug nephrotoxicity and diabetic nephropathy, H₂S serves an important role in both the occurrence and development of the disease. The present review aimed to summarize the production, metabolism and physiological functions of H₂S, and the progress in research with regards to its role in renal injury and renal fibrosis in recent years.