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Circadian disruption in lung cancer
Nidhi Nagariya1, Kaushal Chaudhari1, Vihas T Vasu1,2
1Genomics and Systems Biology Lab, Department of Zoology, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Chronobiology International
|August 9, 2021
Summary
Disrupted circadian rhythms, the body's internal clock, are linked to increased lung cancer risk and poorer outcomes. Understanding these disruptions may lead to new chronotherapy treatments for lung cancer.
Area of Science:
- Oncology
- Chronobiology
- Molecular Biology
Background:
- Lung cancer remains a leading cause of global cancer mortality despite treatment advances.
- Circadian rhythms, regulated by the suprachiasmatic nucleus, are fundamental to cellular and organismal homeostasis.
- Disturbances in circadian rhythms are increasingly recognized as a risk factor for various diseases, including cancer.
Purpose of the Study:
- To explore the association between circadian rhythm disturbances and lung cancer development and prognosis.
- To highlight the potential of chronotherapy in improving lung cancer care.
Main Methods:
- Review of existing research on circadian rhythms and their disruption.
- Analysis of the molecular mechanisms linking circadian disruption to cancer pathogenesis.
- Exploration of chronotherapy principles in the context of lung cancer treatment.
Main Results:
- Circadian clock disruption affects metabolism and cell division, potentially leading to cancer.
- Circadian disturbance is identified as a carcinogen and a risk factor for lung cancer.
- Evidence suggests a link between somatic and systemic circadian rhythm disturbances and higher lung cancer risk and poor prognosis.
Conclusions:
- Understanding the interplay between circadian rhythms and cell division is crucial for novel lung cancer therapies.
- Chronotherapy offers promising avenues for enhancing current lung cancer treatment strategies.
- Further research into molecular interactions could revolutionize lung cancer and other disease treatments.
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