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Reported Signs, Symptoms, and Diagnostic Tests Before Cardiotoxicity Among Women With Breast Cancer: A Pilot Study
The Journal of Cardiovascular Nursing
|August 9, 2021
Summary
Identifying early signs of cardiotoxicity in breast cancer patients is crucial. This study found changes in liver enzymes and kidney function may indicate increased risk of heart damage during cancer treatment.
Area of Science:
- Oncology
- Cardiology
- Biochemistry
Background:
- Cardiotoxicity is a serious complication for breast cancer patients undergoing cancer treatment.
- Currently, no reliable method exists to identify patients at high risk for developing cardiotoxicity.
Purpose of the Study:
- To quantify clinical signs, symptoms, and laboratory values in breast cancer patients who developed cardiotoxicity.
- To explore potential biomarkers for early detection of cardiotoxicity.
Main Methods:
- Retrospective analysis of clinical data from 15 breast cancer patients who experienced cardiotoxicity.
- Utilized Spearman correlation and nonparametric statistical tests to analyze laboratory values and clinical characteristics.
Main Results:
- Significant differences in alanine aminotransferase levels were observed in the 6 months preceding cardiotoxicity (P = .03).
- A negative correlation was noted between estimated glomerular filtration rate and the onset of cardiotoxicity signs/symptoms (Spearman's ρ = -0.5, P = .06).
Conclusions:
- Investigating pre-cardiotoxicity clinical characteristics is vital for understanding underlying mechanisms.
- Identifying these characteristics may help in pinpointing high-risk breast cancer patients for proactive cardiac monitoring.
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