Related Experiment Video

Updated: Jun 23, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

13.7K

Cortical thickness in clinical moyamoya disease: A magnetic resonance imaging study

Grace Tompkins1, Jacob Levman2, Prahar Ijner2

  • 1Department of Mathematics and Statistics, St. Francis Xavier University, Antigonish, Nova Scotia, Canada.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|August 9, 2021
PubMed

Insights

Moyamoya disease (MMD) shows abnormal cortical thickness in several brain regions, including the middle temporal visual area. This study used MRI and machine learning to identify these changes, offering new insights into MMD

Area of Science:

  • Neuroimaging
  • Cerebrovascular Disorders
  • Neurology

Background:

  • Moyamoya disease (MMD) is a progressive cerebrovascular disorder with unknown causes.
  • It involves internal carotid artery stenosis and abnormal collateral vessels (moyamoya vessels).
  • MMD patients experience diverse neurological deficits, including transient ischemic attacks and stroke.

Purpose of the Study:

  • To investigate structural T1 magnetic resonance imaging (MRI) for characterizing abnormal cortical development in MMD.
  • To analyze regional cortical thickness and its variability in MMD patients.
  • To assess the predictive capacity of cortical thickness abnormalities using machine learning.

Main Methods:

  • Analysis of regional cortical thickness and variability from 993 neurotypical control MRI scans and 269 MMD patient MRI scans.
  • Utilized structural T1 MRI for detailed brain imaging.
  • Employed machine learning algorithms to evaluate predictive capabilities of identified cortical abnormalities.

Main Results:

  • Demonstrated abnormal cortical thickness in the insula, caudate, postcentral, precuneus, and cingulate regions.
  • Identified novel cortical thickness abnormalities in the middle temporal visual area in MMD patients.
  • Reported, for the first time, abnormal cortical thickness variability in MMD.

Conclusions:

  • Structural T1 MRI can characterize abnormal cortical development in MMD.
  • Cortical thickness and variability analysis provides valuable insights into MMD pathophysiology.
  • Findings align with previous studies and offer new targets for MMD research and diagnosis.
Keywords:
cortical thicknessmachine learningmagnetic resonance imagingmoyamoyapaediatric

More Related Videos

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

14.3K
Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice06:59

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice

Published on: January 23, 2019

18.0K

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...