Effect of Polyphenols Intake on Obesity-Induced Maternal Programming
Isabela Monique Fortunato1, Tanila Wood Dos Santos1, Lucio Fábio Caldas Ferraz1
1Post Graduate Program in Health Science, Universidade São Francisco (USF), Bragança Paulista 12916-900, SP, Brazil.
Nutrients
|August 10, 2021
Summary
Maternal obesity can negatively impact offspring
Area of Science:
- Nutrition and Dietetics
- Developmental Biology
- Epigenetics
Background:
- Maternal obesity is a growing public health concern linked to offspring metabolic disorders.
- Maternal obesity can epigenetically program fetal development, increasing obesity risk across generations.
- Effective interventions are needed to counteract these adverse developmental effects.
Purpose of the Study:
- To review the impact of dietary polyphenols on maternal obesity-induced reprogramming.
- To explore polyphenols as an anti-obesity strategy for offspring.
Main Methods:
- Literature review of studies investigating dietary polyphenols and maternal obesity.
- Analysis of polyphenol mechanisms, including antioxidant and anti-inflammatory effects.
- Examination of placental transfer and fetal protection.
Main Results:
- Polyphenols demonstrate anti-obesity effects via antioxidant and anti-inflammatory actions.
- Certain polyphenols can cross the placenta, mitigating fetal obesity predisposition.
- Dietary polyphenols counteract negative programming effects of maternal obesity on offspring.
Conclusions:
- Dietary polyphenols show promise in preventing obesity programming caused by maternal obesity.
- Polyphenol supplementation may offer a transgenerational approach to combatting offspring obesity.
- Further research into specific polyphenols and their efficacy is warranted.
More Related Videos
09:10Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
11.0K
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.9K
Related Concept Videos
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
33
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
33
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
43
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
43
01:24Obesity
782
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
782
01:20Pathophysiology of Diabetes
2.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.2K