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Updated: Oct 25, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Adiponectin in psoriasis and its comorbidities: a review
Bai Ruiyang1, Adriana Panayi2, Wu Ruifang1
1Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Lipids in Health and Disease
|August 10, 2021
Summary
Psoriasis, an immune-mediated skin disease, is linked to metabolic issues like diabetes. This review explores adiponectin
Area of Science:
- Immunodermatology
- Metabolic Syndrome
- Adipose Tissue Biology
Background:
- Psoriasis is a chronic inflammatory skin condition involving T cells and keratinocyte proliferation.
- Psoriasis is frequently associated with metabolic comorbidities including obesity, insulin resistance, and diabetes.
- Adipokines, secreted by adipose tissue, play a crucial role in immune and metabolic regulation.
Purpose of the Study:
- To review the role of adiponectin in the pathophysiology of psoriasis.
- To examine the connection between adiponectin and psoriasis comorbidities.
- To identify future research directions concerning adiponectin and psoriasis.
Main Methods:
- Literature review of studies on psoriasis, adiponectin, and metabolic comorbidities.
- Analysis of the molecular and cellular mechanisms linking adiponectin to psoriasis.
- Synthesis of current evidence on adiponectin's impact on psoriasis pathogenesis and associated conditions.
Main Results:
- Adiponectin levels and function are altered in patients with psoriasis.
- Adiponectin influences key inflammatory pathways implicated in psoriasis.
- Dysregulated adiponectin signaling contributes to metabolic dysfunctions seen in psoriasis patients.
Conclusions:
- Adiponectin is a significant factor in the interplay between psoriasis and metabolic health.
- Targeting adiponectin pathways may offer therapeutic potential for psoriasis and its comorbidities.
- Further research is needed to fully elucidate adiponectin's complex role and therapeutic implications.
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