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Next-generation anti-VEGF agents for diabetic macular oedema
Matias Iglicki1, David Pérez González2, Anat Loewenstein2
1Private Retina Office, University of Buenos Aires, Buenos Aires, Argentina. matiasiglicki@gmail.com.
Eye (London, England)
|August 10, 2021
Summary
New long-lasting treatments for diabetic macular oedema (DMO) may bridge the gap between clinical trials and real-world outcomes. These advancements aim for better patient results with fewer injections.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Intravitreal injections have improved diabetic macular oedema (DMO) treatment and outcomes.
- Real-world data show a significant gap between randomized clinical trial results and daily practice for DMO.
- Treatment burden and frequent injections contribute to suboptimal outcomes in clinical practice.
Purpose of the Study:
- To review emerging long-lasting intravitreal therapies for DMO.
- To evaluate the potential of new drugs and devices to reduce the disparity in DMO treatment outcomes.
- To assess the pharmacodynamics, clinical trial results, and safety of novel DMO treatments.
Main Methods:
- Review of pharmacodynamics and preliminary clinical trial data.
- Analysis of safety profiles for new DMO treatments.
- Inclusion of brolucizumab, faricimab, conbercept, KSI-301, and a port-delivery system (WR42221).
Main Results:
- Preliminary data suggest potential for improved efficacy and durability.
- Novel agents and delivery systems show promise in early studies.
- Safety profiles are under ongoing investigation across multiple agents.
Conclusions:
- Long-lasting intravitreal treatments offer a potential solution to improve real-world DMO management.
- These advancements may help control the global epidemic of diabetic eye disease.
- Further research and real-world evidence are crucial for widespread adoption.
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