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Autologous Lipoaugmentation Long-Term Clinical Outcomes: A Systematic Review
Alex S Luke1,2, Ashley M Logan2, Alexandria E Gawlik2
1Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, U.S.A.
The Laryngoscope
|August 10, 2021
Summary
Vocal fold lipoaugmentation offers long-term benefits for glottal insufficiency, though effectiveness may gradually decrease over time. Most patients report sustained improvement in voice and swallowing function post-procedure.
Area of Science:
- Otolaryngology
- Regenerative Medicine
- Surgical Outcomes Research
Background:
- Vocal fold (VF) lipoaugmentation is a treatment for glottal insufficiency.
- Data on the long-term effectiveness of VF lipoaugmentation are variable.
Purpose of the Study:
- To systematically review published long-term outcomes of VF lipoaugmentation.
- To compile data on the duration of effectiveness for VF lipoaugmentation.
Main Methods:
- A systematic literature search was conducted in September 2020.
- 31 studies totaling 764 patients were included in the final analysis.
- Data on patient-reported outcomes, objective findings, and additional procedures were collected.
Main Results:
- Most patients (98.6%) reported initial improvement in voice and/or swallowing.
- Within the first year, 11.7% of patients experienced regression.
- Beyond one year, 12.6% of patients reported regression from initial improvement up to 8 years.
Conclusions:
- Vocal fold lipoaugmentation provides long-term benefits for glottal insufficiency.
- While improvements may taper, sustained positive outcomes are common.
- Further research may explore factors influencing long-term efficacy.
