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Updated: Oct 25, 2025

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
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Circadian rhythms and pain.

Jacob R Bumgarner1, William H Walker1, Randy J Nelson1

  • 1Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.

Neuroscience and Biobehavioral Reviews
|August 10, 2021
PubMed
Summary
This summary is machine-generated.

Circadian rhythms influence pain perception. Disrupted biological clocks can worsen chronic pain, suggesting a complex interplay between the body

Keywords:
Chronic painCircadian rhythm disruptionCircadian rhythmsCircadian rhythms and painCircadian rhythms of painPainPain system

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Pain Research

Background:

  • The interplay between biological rhythms and pain processing is increasingly recognized.
  • Understanding circadian influences on pain is crucial for developing effective pain management strategies.

Purpose of the Study:

  • To review the relationship between circadian and pain systems.
  • To highlight the role of circadian rhythm disruption in maladaptive pain.
  • To propose a model for the complex interactions within the pain system.

Main Methods:

  • Literature review of direct and correlative evidence.
  • Analysis of diurnal and circadian rhythms in pain.
  • Synthesis of findings on feedback loops between circadian disruption and pain.

Main Results:

  • Evidence demonstrates diurnal and circadian rhythms within the pain system.
  • Circadian rhythm disruption may contribute to maladaptive pain.
  • No single area controls pain rhythms; it's a distributed function.

Conclusions:

  • Circadian rhythms of pain arise from distributed rhythms in the pain system.
  • The descending pain modulatory system plays a key role.
  • Interactions with opioid, endocrine, and immune systems are critical.