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Stable behavioral state-specific large scale activity patterns in the developing cortex of neonates.

Nima Mojtahedi¹, Yury Kovalchuk¹, Alexander Böttcher²

¹Institute of Physiology, Department of Neurophysiology, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany.

|August 10, 2021

Summary

This summary is machine-generated.

Researchers mapped intrinsic neuronal activity in neonatal mouse brains, revealing distinct patterns during rest and motion. These stable, state-specific maps provide a unified view of developing brain activity.

Keywords:

Functional long-range connections Intrinsic network activity Large-scale in vivo Ca(2+) imaging Propagating waves State-specific activity maps Stationary waves

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Area of Science:

Neuroscience
Developmental Biology
Computational Neuroscience

Background:

Intrinsic neuronal activity is crucial for brain development.
Previous studies lacked a macroscopic view of these activities in the developing cortex.
Understanding these patterns is key to deciphering cortical wiring.

Purpose of the Study:

To create a unifying macroscopic map of intrinsic neuronal activity in the neonatal mouse dorsal cortex.
To identify behavioral state-specific activity patterns.
To understand the role of intrinsic activity in early brain development.

Main Methods:

Large-scale in vivo Ca2+ imaging in non-anesthetized neonatal mice.
Mathematical analyses of imaging data.
Mapping of dorsal cortical activity.

Main Results:

Unique, stable, and reproducible behavioral state-specific maps of intrinsic activity were revealed.
Activity patterns during motion and rest were nearly inverse, with distinct regional specializations.
Stationary and propagating waves, along with correlated activity patches, formed the basis of these maps.
The retrosplenial cortex showed dynamic engagement in both activity states via long-range connections.

Conclusions:

The study provides a consistent, large-scale picture of intrinsic neuronal activity in the developing brain.
These findings integrate previously disparate regional observations.
The results lay the groundwork for future studies on the functional role of these activity patterns in cortical development.