Hybrid membranes for the production of blood contacting surfaces: physicochemical, structural and biomechanical characterization
Related Experiment Video
Updated: Oct 25, 2025
Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture
Published on: December 26, 2017
Martina Todesco1,2, Carlo Zardin1, Laura Iop3
1Department of Industrial Engineering, University of Padua, via Marzolo 9, 35131, Padova, Italy.
Background:
Due to the shortage of organs' donors that limits biological heart transplantations, mechanical circulatory supports can be implanted in case of refractory end-stage heart failure to replace partially (Ventricular Assist Device, VAD) or completely (Total Artificial Heart, TAH) the cardiac function. The hemocompatibility of mechanical circulatory supports is a fundamental issue that has not yet been fully matched; it mostly depends on the nature of blood-contacting surfaces.
Methods:
In order to obtain hemocompatible materials, a pool of hybrid membranes was fabricated by coupling a synthetic polymer (polycarbonate urethane, commercially available in two formulations) with a decellularized biological tissue (porcine pericardium). To test their potential suitability as candidate materials for realizing the blood-contacting surfaces of a novel artificial heart, hybrid membranes have been preliminarily characterized in terms of physicochemical, structural and mechanical properties.
Results:
Our results ascertained that the hybrid membranes are properly stratified, thus allowing to expose their biological side to blood and their polymeric surface to the actuation system of the intended device. From the biomechanical point of view, the hybrid membranes can withstand deformations up to more than 70 % and stresses up to around 8 MPa.
Conclusions:
The hybrid membranes are suitable for the construction of the ventricular chambers of innovative mechanical circulatory support devices.
