Related Experiment Video
Updated: Oct 25, 2025
07:55
Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
Published on: May 31, 2011
10.5K
Regulatory mechanisms ensuring coordinated expression of functionally related genes
Oriana Q H Zinani1, Kemal Keseroğlu2, Ertuğrul M Özbudak1
1Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Trends in Genetics : TIG
|August 11, 2021
Summary
Organisms use gene coexpression strategies like operons and gene clusters for development and homeostasis. Advanced tools can now test the functional importance of these gene organization methods.
Area of Science:
- Genomics
- Molecular Biology
- Systems Biology
Background:
- Coordinated gene expression is crucial for organism development and homeostasis.
- Organisms employ diverse strategies such as operons, gene clustering, and enhancer sharing to achieve coexpression.
- Coexpression is hypothesized to regulate gene expression variability, protein complex stoichiometry, and metabolite levels.
Purpose of the Study:
- To explore the functional significance of various gene coexpression strategies.
- To investigate how gene organization impacts biological processes.
Main Methods:
- Utilizing gene-editing tools and computational modeling to study adjacent gene pairs and clusters.
- Leveraging advancements in gene editing, single-cell sequencing, and imaging technologies.
Main Results:
- Recent studies have begun testing the advantages of adjacent gene organization.
- The proposed research framework enables functional testing of coexpression strategies.
Conclusions:
- Diverse coexpression strategies are essential for biological regulation.
- Future research using advanced tools can elucidate the functional importance of these strategies in various biological contexts.
More Related Videos
Related Concept Videos
01:23Regulation of Expression at Multiple Steps
1.1K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.1K
02:24Regulation of Expression Occurs at Multiple Steps
23.9K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
23.9K
02:24Regulation of Expression Occurs at Multiple Steps
3.3K
3.3K
02:33Combinatorial Gene Control
8.7K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.7K
01:27Constitutive and Regulated Gene Expression
288
Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
288
02:13Cooperative Binding of Transcription Regulators
6.8K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome. Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
6.8K