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Updated: Oct 25, 2025

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Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
Published on: September 9, 2020
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Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases
Takahiro Mitsumura1, Yuichi Kumaki2, Kenta Takahashi3
1Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Thoracic Cancer
|August 11, 2021
Abstract:
Of the 80 solid tumor cases in which liquid biopsy (LB) was performed using Guardant360 in the PROFILE study, nine were lung cancer cases. Here, we review three cases in which LB was useful in diagnosing ALK fusion-positive lung cancer, selecting sequential ALK-tyrosine kinase inhibitors, confirming uncommon EGFR mutations, and receiving biomarker-compatible therapy.

