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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Infertility in Females01:28

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Infertility in Males01:23

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Fertilization01:38

Fertilization

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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
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Development of the Sexual Organs in the Embryo and Fetus01:15

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Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
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Meiosis II01:57

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Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
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Systematic development of a mobile preconception lifestyle programme for couples undergoing IVF: the

T Boedt1,2, C Matthys1,3, S Lie Fong2,4

  • 1Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.

Human Reproduction (Oxford, England)
|August 11, 2021
PubMed
Summary

A new mobile preconception lifestyle program, PreLiFe, was developed for couples undergoing IVF. This program offers tailored advice on diet, exercise, and stress reduction to potentially improve IVF success rates.

Keywords:
lifestyle intervention / infertility / diet / physical activity / mindfulness / telemedicine / healthy lifestyle / patient-centred care / preconceptionmHealth

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Area of Science:

  • Reproductive Medicine
  • Health Behavior Change
  • Digital Health Interventions

Background:

  • A healthy lifestyle preconception is crucial for reproductive health and offspring well-being.
  • Emerging evidence highlights the importance of preconception health for IVF outcomes.
  • Currently, few fertility clinics offer structured lifestyle programs for IVF patients.

Purpose of the Study:

  • To develop a preconception lifestyle program tailored to the needs of couples undergoing In Vitro Fertilization (IVF).
  • To create an evidence-based and patient-centered intervention to support lifestyle modifications during IVF treatment.

Main Methods:

  • The PreLiFe-programme was developed using the Medical Research Council (MRC) framework for complex interventions.
  • Methods included literature reviews, expert consensus, and incorporating quantitative/qualitative data from IVF patients.
  • The program was refined through user testing with experts and patients, and pilot testing.

Main Results:

  • The PreLiFe-programme is a mobile application offering blended care (app + telephone support) for both partners.
  • It provides tailored advice and skills training on physical activity, diet, and mindfulness-based stress reduction.
  • Patient and expert feedback indicated the program is likely acceptable and meets patient needs for lifestyle guidance.

Conclusions:

  • The developed PreLiFe-programme is a potentially valuable tool for supporting IVF couples' lifestyle choices.
  • Further research is needed to confirm its feasibility for longer durations and in diverse infertile populations.
  • An ongoing trial will assess the program's effectiveness in improving lifestyle and IVF success rates.