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High-Dose Daptomycin Is Well Tolerated via 2-Minute IV Push Administration

Christian M Gill1, Rachel M Kenney1, Charles T Makowski1

  • 1Henry Ford Hospital, Detroit, MI, USA.

Hospital Pharmacy
|August 12, 2021
PubMed
Abstract

Insights

High-dose daptomycin (HDD) administered via intravenous push (IVP) showed comparable safety to traditional intravenous piggyback (IVPB) infusions. Infusion-related reactions occurred in only 1% of patients, regardless of the infusion method.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Infectious Diseases

Background:

  • High-dose daptomycin (HDD) is increasingly used.
  • Traditional administration involves a 30-minute intravenous piggyback (IVPB) infusion.
  • Alternative, faster administration methods are being explored for efficiency and patient convenience.

Purpose of the Study:

  • To evaluate the safety of administering HDD via a rapid 2-minute intravenous push (IVP).
  • To compare the incidence of infusion-related reactions (IRRs) between IVP and IVPB methods for HDD.

Main Methods:

  • Retrospective cohort study design.
  • Compared patients receiving HDD via IVP versus IVPB.
  • Primary outcome: proportion of patients with documented IRR to daptomycin.

Main Results:

  • 300 patients included (200 IVP, 100 IVPB) with 1697 administrations.
  • Median doses were comparable between groups (approx. 700 mg, >8 mg/kg).
  • IRRs occurred in 1% of patients in both the IVP and IVPB groups.

Conclusions:

  • Administering HDD via a 2-minute IVP is safe and comparable to traditional IVPB infusion.
  • Low incidence of IRRs (1%) suggests this method is well-tolerated.
  • IVP administration of HDD may be beneficial in fluid-restricted settings and outpatient care.
Keywords:
daptomycininfusion intravenousmedication safetypharmaceutical preparations

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