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Amber light treatment produces hyperopia in tree shrews
Safal Khanal1, Thomas T Norton1, Timothy J Gawne1
1Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Summary
Amber light exposure induced hyperopia in tree shrews when applied broadly, but not when delivered via goggles. This suggests light delivery method is crucial for controlling refractive error development.
Area of Science:
- Ophthalmology
- Vision Science
- Animal Models
Background:
- Red light exposure, targeting long-wavelength sensitive (LWS) cones, inhibits eye growth and causes hyperopia in animal models.
- Amber light, also stimulating LWS cones but with higher illuminance, was investigated for similar effects.
Purpose of the Study:
- To determine if amber light exposure induces hyperopia in tree shrews, similar to red light.
- To compare the effects of ambient amber light versus goggle-delivered amber light on refractive error.
Main Methods:
- Tree shrews were exposed to amber light either ambiently (Filter group) or via goggles (Goggle group).
- Control animals (Colony group) were exposed to standard fluorescent lighting.
- Refractive error and ocular dimensions were measured daily.
Main Results:
- The Filter group developed significant hyperopia (3.5 D) compared to control and goggle groups.
- The Goggle group (0.2 D) and Colony group (1.0 D) showed normal emmetropization.
- Vitreous chamber changes correlated with refractive error shifts.
Conclusions:
- Ambient amber light exposure can induce hyperopia in tree shrews.
- Goggle-delivered amber light did not induce hyperopia, possibly due to simultaneous short-wavelength sensitive (SWS) cone activation.
- Light delivery method influences refractive error development.
