[The effect of selected disintegrants on the properties of three hydrochlorothiazide tablet formulations]

The admixture of disintegrants was investigated in three different hydrochlorothiazide formulations with respect to tablet properties. Sodiumcarboxymethyl starchs, Na-CMS (Explotab, Primojel, Na-CMS AB-G.D.R.), cross-linked polyvinylpyrrolidone, CL PVP (Polyplasdone) and potato starch were applied. The investigations were especially aimed at the alteration of tablet properties in dependence on compressive force. Considering the values of decomposition and compressive strength Polyplasdone XL has been proved to be the most effective disintegrant for the hydrochlorothiazide formulations investigated. Potato starch shows the worst results. There are only slight differences between the three Na-CMS.