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Related Experiment Video

Updated: Oct 24, 2025

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
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Case presentation and panel discussion: Critical illness.

Manpreet S Mundi1, Jayshil J Patel2, Jeffrey I Mechanick3

  • 1Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

JPEN. Journal of Parenteral and Enteral Nutrition
|August 12, 2021
PubMed
Summary
This summary is machine-generated.

Critical care nutrition support remains controversial despite growing evidence. Experts discuss key clinical dilemmas, including evidence hierarchy, malnutrition assessment, protein dosing, fiber use, and gut-focused therapies.

Keywords:
critical carecritical illnessmicrobiomenutritionnutrition supportprotein

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Area of Science:

  • Critical care medicine
  • Clinical nutrition
  • Gastroenterology

Background:

  • Controversies persist regarding optimal nutrition support in critically ill patients.
  • Evidence-based guidelines for nutrition therapy are continually evolving.
  • Effective nutrition management is crucial for patient outcomes in intensive care units.

Observation:

  • A case of a 60-year-old male with esophageal cancer experiencing acute hypoxemic respiratory failure and septic shock served as a clinical anchor.
  • Five experts from the American Society of Parenteral and Enteral Nutrition (ASPEN) 2021 Pre-Conference convened to discuss critical care nutrition.
  • Key clinical dilemmas were identified and debated during the session.

Findings:

  • The discussion highlighted the challenges in establishing a clear hierarchy of evidence for nutrition interventions.
  • Methods for bedside evaluation of malnutrition in critically ill patients were critically examined.
  • Optimal protein dosing strategies and the role of fiber in critical care nutrition were debated.
  • Emerging therapies targeting gut function and the gut microbiota were considered.

Implications:

  • Addressing these persistent controversies is essential for advancing the practice of critical care nutrition.
  • Improved understanding and application of evidence can lead to better patient outcomes.
  • Future research should focus on resolving these clinical dilemmas to optimize nutrition support.