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A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
[Quantitative study of diffuse increased 99mTc-methylene diphosphonate accumulation of both kidneys]
T Takahashi1, N Kakuhara, S Katsuragawa
1Department of Radiology, Iwate Medical University, Morioka-shi, Japan.
Radioisotopes
|October 1, 1987
Summary
Diffuse increased kidney uptake on bone scintigraphy is rare, affecting 0.63% of patients. A quantitative index using kidney-to-lumbar vertebra ratios can identify this finding.
Area of Science:
- Nuclear medicine
- Radiology
- Medical imaging
Background:
- 99mTc-MDP bone scintigraphy is a common imaging technique.
- Diffuse increased uptake in both kidneys is an uncommon finding.
- Quantitative analysis may improve diagnostic accuracy.
Purpose of the Study:
- To quantitatively evaluate patients with diffuse increased uptake in both kidneys on 99mTc-MDP bone scintigraphy.
- To establish a quantitative index for this finding.
Main Methods:
- Retrospective analysis of 1,100 bone scintigrams.
- Identification of 7 cases (0.63%) with diffuse increased kidney uptake.
- Quantitative comparison of kidney/lumbar vertebra accumulation density ratios between patients and controls using A/D exchanged images.
Main Results:
- The patient group with diffuse increased kidney uptake showed statistically higher kidney/lumbar vertebra accumulation density ratios compared to the control group.
- This quantitative ratio serves as a reliable index.
Conclusions:
- The accumulation density ratio of kidneys/lumbar vertebra in A/D exchanged images is a valid index for identifying diffuse increased accumulation in both kidneys on 99mTc-MDP bone scintigraphy.
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