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HMGB1 released from nociceptors mediates inflammation.

Huan Yang1, Qiong Zeng2, Harold A Silverman2

  • 1Laboratory of Biomedical Sciences, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030; HYang@northwell.edu schavan@northwell.edu kjtracey@northwell.edu.

Proceedings of the National Academy of Sciences of the United States of America
|August 13, 2021
PubMed
Summary

Nociceptor release of High Mobility Group Box 1 (HMGB1) contributes to neurogenic inflammation and pain. Silencing neuronal HMGB1 protected mice from inflammation and allodynia in injury and arthritis models.

Keywords:
DAMPHMGB1arthritiscytokinesciatic nerve injury

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