Related Experiment Video
Updated: Aug 7, 2026

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
Published on: January 6, 2015
A simple method of correcting diffusing capacity for alveolar volume reduction in restrictive lung diseases
N González Mangado1, M J Avilés Inglés, G Peces-Barba
1Servicio de Neumología, Fundación Jiménez Díaz, Ciudad Universitaria, Madrid, España.
Abstract:
We studied the discriminative power of the transfer factor (TLCO), KCO (TLCO/Va) and ZCO (a corrected TLCO according to alveolar volume measured (Va), introduced by our group), in order to differentiate diffuse interstitial disease from other restrictive diseases. Measurements were taken in 46 subjects, divided into two groups: Pure restriction (group 1: normal subjects with voluntary restriction and diseased subjects) and (2) diffuse interstitial restriction (group 2). There were no statistical differences in Va between groups 1 and 2. TLCO was statistically lower in groups 1 and 2 in comparison with the control group (normal values of our laboratory in test with Va greater than 90% of predicted) and showed a significant difference when group 1 was compared with group 2. Similar results (but with higher values than those of the control group) were found for KCO. A similar difference exists in ZCO only when group 2 is compared with group 1, but not when group 1 is compared with the control group. The corrected diffusion capacity ZCO yields the highest discriminative power.
More Related Videos
07:09Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
Published on: February 20, 2017
08:44Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
Published on: February 2, 2024
Related Concept Videos
Breathing
Respiratory Volumes
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Pulmonary Cycle: Exhalation
Respiratory Volumes and Capacities
External and Internal Respiration
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...