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Updated: Oct 24, 2025
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
In vitro and in vivo evaluation of virus-induced innate immunity in mouse
Long Shen1, Xiao Shan1, Penghui Hu1
1Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Abstract:
Innate immunity is the first line of host defense against viral infection. As one of the innate immune cell types, antigen-presenting cells play an important role in the process of antiviral immunity. This protocol describes the analysis of innate immunity induced by vesicular stomatitis virus infection of peritoneal macrophages in vitro and in vivo detection of IFN-β production and lung injury. For complete details on the use and execution of this protocol, please refer to Shen et al. (2021).
