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Critical Functions of lncRNA DGCR5 in Cancers of the Digestive System
Chengyu Hu1, Wen Xu1, Bei Wang1
1College of Medical Science, China Three Gorges University, Yichang 443002, China.
Background:
Long non-coding RNAs (lncRNAs) has no protein-coding potential due to the lack of an apparent open reading frame. There is growing evidence that lncRNA DGCR5 has a vital regulatory role in human illnesses' pathological development, particularly in the digestive system's carcinogenesis and progression. Abnormal DGCR5 expression affects different cellular functions such as proliferation, aggression, and metastasis. This paper aims to probe into the pathophysiological functions and molecular mechanisms of DGCR5 in cancers of the digestive system.
Methods:
This review summarizes and analyzes the biological functions and mechanisms of lncRNA DGCR5 in digestive system cancers occurrence. Relevant studies were conducted and reviewed by searching PubMed for articles with lncRNA DGCR5 and digestive system cancer as keywords in recent years.
Results:
DCGR5, as a novel tumor-related lncRNA, is recently identified to be abnormally expressed in digestive system cancers, such as pancreatic ductal adenocarcinoma, pancreatic cancer, gastric cancer, gallbladder cancer, colorectal cancer, and hepatocellular carcinoma. The role played by DCGR5 is vital and varies in different digestive cancers. Taken together, aberrant expression of DCGR5 regulates the progression of digestive cancers by affecting cancer cell proliferation, aggression, metastasis, and drug resistance.
Conclusion:
LncRNA DGCR5 might be a viable marker or a promising therapeutic target in digestive system cancers.
Insights
Long non-coding RNA DGCR5 (lncRNA DGCR5) plays a key role in digestive system cancers. Aberrant DGCR5 expression influences cancer progression, making it a potential therapeutic target.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) lack protein-coding potential.
- lncRNA DGCR5 is increasingly recognized for its regulatory role in human diseases, especially digestive system cancers.
- Abnormal DGCR5 expression impacts cellular functions like proliferation, aggression, and metastasis.
Purpose of the Study:
- To investigate the pathophysiological functions of lncRNA DGCR5 in digestive system cancers.
- To elucidate the molecular mechanisms underlying DGCR5's role in digestive cancer development.
Main Methods:
- Literature review of studies on lncRNA DGCR5 and digestive system cancers.
- PubMed search using keywords: lncRNA DGCR5 and digestive system cancer.
- Analysis of biological functions and mechanisms of DGCR5 in digestive cancers.
Main Results:
- DGCR5 is abnormally expressed in various digestive system cancers, including pancreatic, gastric, gallbladder, colorectal, and hepatocellular carcinomas.
- DGCR5's role is significant and varies across different digestive cancers.
- Aberrant DGCR5 expression regulates cancer cell proliferation, aggression, metastasis, and drug resistance.
Conclusions:
- lncRNA DGCR5 is implicated in the progression of digestive system cancers.
- DGCR5 may serve as a potential diagnostic marker or therapeutic target for digestive system cancers.
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