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Fixation of Transparent Bone Pins with Photocuring Biocomposites.

Gautama Wicaksono1, Felicia Toni1, Leonard Wei Feng Tok1

  • 1School of Materials Science and Engineering (MSE), Nanyang Technological University (NTU), 639798 Singapore.

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|August 13, 2021
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Summary

New bone fixation uses light-activated biopolymers to rapidly secure fractures, potentially avoiding repeat surgeries. This innovative method offers faster healing and improved bone integration without traditional metal implants.

Keywords:
bioglassbone biocompositebone−implant fixationhydroxyapatitepolymer bioadhesive

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Polymer Chemistry

Background:

  • Current bone fracture fixation relies on metal implants (pins, screws), often requiring secondary surgeries for removal.
  • There is a clinical need for rapid bone fixation methods that minimize surgical interventions and improve healing outcomes.

Purpose of the Study:

  • To introduce a novel bone fixation technique using transparent biopolymers activated by light-cured bioadhesives.
  • To evaluate the efficacy of CaproGlu bioadhesives and osseointegration additives for enhanced bone fixation.

Main Methods:

  • Development of a bone fixation system employing transparent biopolymers and UV-light-activated CaproGlu bioadhesives.
  • Incorporation of hydroxyapatite or Bioglass 45S5 as osseointegration additives into the biocomposite matrix.
  • Assessment of structure-property relationships, including UV dose, pin diameter, viscosity, modulus, curing, and adhesion, using ex vivo bone models.

Main Results:

  • The CaproGlu bioadhesives, activated by UV light guided through transparent biopolymers, expand and form a covalently cross-linked matrix.
  • Addition of hydroxyapatite or Bioglass 45S5 significantly increased the stiffness and pullout strength of the biocomposite.
  • Structure-property analyses revealed relationships between UV dose, pin diameter, additives, and fixation performance metrics.

Conclusions:

  • The proposed UV-active transparent biopolymer fixation system offers a promising alternative to traditional metal implants for bone fractures.
  • This method demonstrates potential for rapid, minimally invasive bone fixation with enhanced osseointegration and reduced need for revision surgeries.
  • Further optimization and exploration using ex vivo bone models are recommended to advance this technology.