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Updated: Oct 24, 2025
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Chromophobe Renal Cell Carcinoma with Radiologic-Pathologic Correlation.
Jamie Marko1, Ryan Craig1, Andrew Nguyen1
1From the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md, and American Institute for Radiologic Pathology, Silver Spring, Md (J.M.); F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md (R.C.); George Washington University School of Medicine and Health Sciences, Washington, DC (A.N.); Department of Pathology, University of Michigan Medical School, Ann Arbor, Mich (A.M.U.); and Department of Radiology, Johns Hopkins Hospital and Health System, 5255 Loughboro Rd NW, Washington, DC 20016 (D.J.W.).
Chromophobe renal cell carcinoma (chRCC), a subtype of kidney cancer, is often found incidentally and treated with surgery. It has a better prognosis than clear cell renal cell carcinoma (RCC).
Area of Science:
- Nephrology
- Oncology
- Radiology
Background:
- Renal cell carcinoma (RCC) encompasses diverse neoplasms originating from renal tubular epithelial cells.
- Chromophobe RCC (chRCC) is the third most common RCC subtype, representing 5% of cases.
- chRCC can be asymptomatic incidental findings or present with clinical symptoms.
Purpose of the Study:
- To review the clinicopathologic features of chRCC.
- To correlate imaging findings with pathologic characteristics of chRCC.
- To illustrate the multimodality imaging appearances of chRCC.
Main Methods:
- Review of cases from the American Institute for Radiologic Pathology Archives.
- Emphasis on correlative pathologic findings.
- Illustration of multimodality imaging appearances.
Main Results:
- Gross pathology: Solid, well-defined mass with lobulated borders and moderate vascularity.
- Histology: Varies by subtype; typically large, pale polygonal cells with clear cytoplasm, "raisinoid" nuclei, perinuclear halos, and distinct cell membranes.
- Imaging: Predominantly solid renal mass with circumscribed margins and less enhancement than renal cortex.
Conclusions:
- chRCC has a better prognosis than clear cell RCC.
- Surgical resection is the primary treatment for chRCC.
- Understanding imaging and pathologic features aids in chRCC diagnosis.
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