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Updated: Oct 24, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Acute Q fever in third trimester pregnancy

Maxwell Braddick1, Marion L Woods2,3, Suji Prabhaharan4

  • 1Infectious Diseases, Townsville Hospital and Health Service, Townsville, Queensland, Australia mbraddick@gmail.com.

BMJ Case Reports
|August 14, 2021
PubMed

A 29-year-old gravida 2 para 1 woman presented at 29 weeks gestation with fevers, back pain, thrombocytopenia and hepatitis. PCR testing of blood samples detected Coxiella burnetii and paired serology later confirmed the diagnosis of acute Q fever in pregnancy. The patient was treated empirically with oral clarithromycin and experienced a symptomatic and biochemical improvement. Therapy was changed to oral trimethoprim/sulphamethoxazole but was complicated by a delayed cutaneous reaction, prompting recommencement of clarithromycin. Therapy continued until delivery of a healthy girl at 39 weeks and 3 days. Q fever in pregnancy is likely under-reported and is associated with the development of chronic infection and obstetric complications. Treatment with clarithromycin is an alternative to trimethoprim/sulphamethoxazole in the setting of drug intolerance.

Keywords:
exposuresinfectious diseasesmaterno-foetal medicinepregnancytropical medicine (infectious disease)

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