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Refractory Osteomyelitis.

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Hyperbaric oxygen for refractory osteomyelitis.

Brett B Hart1

  • 1Department of Emergency Medicine and Research Institute of Hyperbaric Medicine and Science, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|August 14, 2021
PubMed
Summary
This summary is machine-generated.

Hyperbaric oxygen (HBO2) therapy, combined with antibiotics and surgery, improves outcomes for refractory osteomyelitis. This treatment is safe and effective, especially when initiated early after debridement.

Keywords:
debridementhyperbaric oxygen therapyosteomyelitisrefractory

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Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Hyperbaric Medicine

Background:

  • Refractory osteomyelitis is a persistent or recurring infection unresponsive to standard treatments.
  • Limited clinical trials exist for hyperbaric oxygen (HBO2) therapy in osteomyelitis.
  • Existing literature suggests HBO2 may benefit refractory cases.

Purpose of the Study:

  • To evaluate the efficacy and safety of hyperbaric oxygen (HBO2) therapy as an adjunct treatment for refractory osteomyelitis.

Main Methods:

  • Comprehensive literature review of HBO2 therapy for refractory osteomyelitis.
  • Analysis of treatment protocols including HBO2, antibiotics, and surgical debridement.
  • Assessment of outcomes based on clinical improvement and infection resolution rates.

Main Results:

  • HBO2 therapy, alongside antibiotics and surgery, appears safe and improves infection resolution rates in refractory osteomyelitis.
  • Optimal results are achieved when HBO2 is combined with culture-directed antibiotics and early surgical debridement.
  • HBO2 therapy offers a viable treatment option for cases where extensive surgery is contraindicated.

Conclusions:

  • Adjunctive hyperbaric oxygen (HBO2) therapy is a promising treatment for refractory osteomyelitis.
  • Treatment involves daily HBO2 sessions (2.0-3.0 ATA) for 4-6 weeks, alongside antibiotics and surgery.
  • Reassessment of treatment is necessary if prompt clinical improvement is not observed.