Effective potentials induced by mixtures of patchy and hard co-solutes

The addition of co-solutes to colloidal suspensions is often employed to induce tunable depletion interactions. In this work, we investigate effective colloidal interactions arising from binary co-solute mixtures of hard spheres and patchy particles. By changing the relative concentration of the two species, we show that the resulting effective potential V_eff continuously changes from the one obtained for a single-component hard sphere co-solute to that mediated by the single-component patchy particle co-solute. Interestingly, we find that, independent of the relative concentration of the two components, the resulting V_eff is additive, i.e., it is well-described by the linear combination of the effective interactions mediated by respective pure co-solutes. However, a breakdown of the additivity occurs when the co-solute mixture is close to the onset of a demixing transition. These results represent a step forward in understanding and predicting colloidal behavior in complex and crowded environments and for exploiting this knowledge to design targeted colloidal superstructures.