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Related Experiment Video

Updated: Oct 24, 2025

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eABR THR Estimation Using High-Rate Multi-Pulse Stimulation in Cochlear Implant Users.

Ali Saeedi1,2, Ludwig Englert1, Werner Hemmert1,2,3

  • 1Department of Electrical and Computer Engineering, Technical University of Munich, Munich, Germany.

Frontiers in Neuroscience
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

Electrically-evoked auditory brainstem response (eABR) thresholds were estimated using multi-pulse stimulation. Multi-pulse stimulation, particularly with 4-16 pulses, showed potential for more accurate estimation of clinical auditory brainstem response thresholds compared to single pulses.

Keywords:
brainstem responsecochlear implantsmulti-pulse stimulationobjective measuretemporal integrationthreshold estimation

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Area of Science:

  • Auditory Neuroscience
  • Neurophysiology
  • Biomedical Engineering

Background:

  • Electrically-evoked auditory brainstem response (eABR) thresholds are crucial for assessing auditory nerve function in cochlear implant users.
  • Estimating eABR thresholds with multi-pulse stimulation at high burst rates (10,000 pulses-per-second) may better reflect clinical stimulation paradigms than single pulses.

Purpose of the Study:

  • To estimate electrically-evoked auditory brainstem response thresholds (eABR THRs) using multi-pulse stimulation.
  • To compare eABR THRs estimated from multi-pulse stimulation with psychophysical and clinical behavioral thresholds.

Main Methods:

  • Calculated growth functions of wave eV amplitudes, RMS values, peak of phase-locking value (PLV), and lowest valid data point (LVDP) for 1-, 2-, 4-, 8-, and 16-pulses conditions.
  • Fitted and extrapolated growth functions using linear and exponential models to determine eABR THRs.
  • Compared estimated eABR THRs with psychophysical THRs and clinical THRs measured at 1,000 pulses-per-second.

Main Results:

  • Growth functions exhibited shallower slopes with increasing pulse numbers.
  • eABR THRs estimated using 4-, 8-, and 16-pulses conditions were closer to clinical THRs than those from 1- and 2-pulses conditions.
  • The smallest absolute difference (30.3 μA) between estimated and clinical THRs was found using linear fitting on eABR RMS values in the 4-pulses condition.

Conclusions:

  • Multi-pulse stimulation, especially with 4-16 pulses, can better represent clinical stimulation paradigms for estimating auditory brainstem response thresholds.
  • eABRs to multi-pulse stimulation may offer more accurate clinical threshold estimations compared to single-pulse stimulation.
  • The optimal number of pulses for minimizing error in eABR threshold estimation varied across different signal features and fitting methods.