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Danazol reverses endometrial hyperplasia to normal endometrium
C Bulletti1, V M Jasonni, S Tabanelli
1Department of Obstetrics and Gynecology, University of Bologna.
Acta Europaea Fertilitatis
|May 1, 1987
Summary
Danazol effectively treats endometrial hyperplasia in postmenopausal women, reversing the condition in 97% of cases. This study highlights danazol
Area of Science:
- Endocrinology
- Gynecology
- Pharmacology
Background:
- Endometrial hyperplasia is a common condition in postmenopausal women.
- Danazol, an isoxazol derivative, has demonstrated potential antiproliferative effects on the endometrium.
Purpose of the Study:
- To evaluate the efficacy of danazol in treating postmenopausal endometrial hyperplasia.
- To assess the antiproliferative effect of danazol on human endometrium.
Main Methods:
- Thirty-one postmenopausal patients with endometrial hyperplasia were treated with danazol.
- The treatment involved a dosage of 400 mg/day for three months.
Main Results:
- Danazol treatment resulted in the reversal of endometrial hyperplasia to normal endometrium in 97% of patients.
- Atrophic changes, indicating normalization, were observed in 68% of patients following danazol therapy.
Conclusions:
- Danazol demonstrates significant efficacy in treating postmenopausal endometrial hyperplasia.
- The compound exhibits a notable antiproliferative effect on the endometrium, supporting its therapeutic potential.