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Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic

Burak Acar1, Cagrı Yayla2, Murat Gul3

  • 1Department of Cardiology, Faculty of Medicine, Kocaeli University, Kocaeli/Turkey.

African Health Sciences
|August 16, 2021
PubMed

Insights

The monocyte count-to-HDL-cholesterol ratio (MHR) is elevated in patients with bicuspid aortic valve and aortic dilatation. This ratio, along with uric acid, is independently associated with aortic dilatation in this patient group.

Area of Science:

  • Cardiology
  • Biomarkers
  • Genetics

Background:

  • The monocyte count-to-HDL-cholesterol ratio (MHR) is a recognized marker in cardiovascular diseases.
  • Ascending aortic dilatation (AAD) is a frequent complication in individuals with bicuspid aortic valve (BAV).

Purpose of the Study:

  • To investigate the association between MHR and the presence of aortic dilatation in patients diagnosed with BAV.

Main Methods:

  • A cohort of 347 patients with BAV was analyzed.
  • Patients were categorized into two groups: those with AAD (ascending aorta diameter ≥ 4.0 cm) and those without.
  • Echocardiographic and laboratory data were collected and compared between groups.

Main Results:

  • MHR was significantly higher in patients with aortic dilatation compared to those without.
  • MHR and uric acid levels were independently correlated with the presence of aortic dilatation in the BAV cohort.

Conclusions:

  • A significant relationship exists between MHR and aortic dilatation in patients with BAV.
Abstract

Keywords:
Bicuspid aortaaorta aneurysminflammationmonocyte HDL ratio

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