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Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing
Haiying Sun1,2, Tian Wang1, Patrick J Atkinson1
1Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States.
Frontiers in Cell and Developmental Biology
|August 16, 2021
Summary
Gpr125 (Adgra3) is dynamically expressed in the developing and mature cochlea. However, Gpr125 is dispensable for mammalian cochlear development and auditory function.
Area of Science:
- Developmental Biology
- Neuroscience
- Genetics
Background:
- G protein-coupled receptors (GPRs) regulate organ development and homeostasis.
- Gpr125 (Adgra3), a GPR adhesion family member, influences Wnt/PCP signaling in zebrafish.
- Its role in mammalian cochlear development remains uncharacterized.
Purpose of the Study:
- To investigate the expression pattern of Gpr125 in the mammalian cochlea.
- To determine the necessity of Gpr125 for cochlear development and auditory function.
Main Methods:
- Utilized Gpr125 knock-in mice for expression analysis.
- Performed in situ hybridization for Gpr125 mRNA.
- Examined cochlear development and auditory physiology in Gpr125 knockout mice.
Main Results:
- Gpr125 exhibits dynamic expression in various cochlear cell types during development and maturity.
- No significant loss or disorganization of sensory or non-sensory cells was observed in Gpr125 knockout cochleae.
- Auditory physiology remained normal in the absence of Gpr125.
Conclusions:
- Gpr125 is expressed in diverse cochlear cell populations throughout development and adulthood.
- Gpr125 is not essential for the development of the mammalian cochlea or normal hearing.
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