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Updated: Oct 24, 2025

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
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Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

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Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer

Hongxu Li1,2,3,4, Jie Gao1,2,3,4, Shuijun Zhang1,2,3,4

  • 1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Cell and Developmental Biology
|August 16, 2021
PubMed

Insights

The cell adhesion molecule CADM1 impacts tumor development by promoting apoptosis and inhibiting proliferation. Low expression correlates with aggressive cancers, suggesting CADM1 as a potential diagnostic biomarker and therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cell adhesion molecule CADM1 regulates cell adhesion and signal transduction.
  • CADM1 involvement in malignant tumors across various organ systems, including respiratory and digestive tracts.
  • Dysregulation of CADM1 impacts tumor progression and patient outcomes.

Purpose of the Study:

  • To investigate the role of CADM1 in tumor development and progression.
  • To explore the association between CADM1 expression levels and clinical characteristics.
  • To identify CADM1 as a potential biomarker for early cancer diagnosis and a therapeutic target.

Main Methods:

  • Analysis of CADM1 expression in tumor tissues.
  • Correlation studies between CADM1 levels and clinicopathological features.
  • Investigation of signaling pathways regulated by CADM1, including EMT, STAT3, and AKT.
  • Exploration of regulatory mechanisms involving lncRNAs and miRNAs on CADM1.

Main Results:

  • Upregulated CADM1 expression promotes tumor cell apoptosis and inhibits malignant proliferation.
  • CADM1 regulates key signaling pathways (EMT, STAT3, AKT), inhibiting invasion and migration.
  • Low CADM1 expression is linked to aggressive tumor phenotypes and poor prognosis.
  • Specific roles of CADM1 in adult T-cell leukemia/lymphoma (ATLL) involving NF-κB.

Conclusions:

  • CADM1 plays a significant role in tumor suppression, affecting proliferation, apoptosis, invasion, and migration.
  • CADM1 expression levels serve as a prognostic indicator for various cancers.
  • CADM1 represents a promising biomarker for early cancer detection and a potential target for novel therapeutic strategies.
Keywords:
CADM1biomarkercancermetastasisproliferation

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