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Updated: Oct 24, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
A one-pot ring-closure and ring-opening sequence for the cascade synthesis of dihydrofurofurans and functionalized
Maruti B Yadav1, Yeon Tae Jeong
1Department of Image Science and Engineering, Pukyong National University, Busan 608-737, Republic of Korea. ytjeong@pknu.ac.kr.
Abstract:
We have developed a simple novel ring-closure and ring-opening pathway using an organo-base system for the synthesis of highly substituted dihydrofurofuran and furan frameworks via a triethylamine-catalyzed one-pot three-component reaction. The protocol involved a Knoevenagel and Michael adduct via Paal-Knorr cyclization with aromatic/aliphatic glyoxal and 2-cyanoacetophenone under mild and heating conditions with excellent yields through a simple filtration method. The merits of this methodology, including the use of easily available feedstocks and an inexpensive catalyst, Gram-scale synthesis, wide functional group tolerance, an open-air reaction setup, and no need for workup and column-chromatography procedures, make the developed methodology a practical way to access dihydrofurofurans and functionalized furans.
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