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Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

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Published on: April 7, 2017

Terpolymer-chitosan membranes as biomaterial.

María Leticia Bravi Costantino^1,2, María Soledad Belluzo¹, Tamara G Oberti¹

¹Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, UNLP-CONICET, La Plata, Argentina.

Journal of Biomedical Materials Research. Part A

|August 16, 2021

Summary

Researchers developed a novel terpolymer (FVH) from diisopropyl fumarate, vinyl benzoate, and 2-hydroxyethyl methacrylate. This biomaterial, combined with chitosan, shows promise for regenerative medicine applications due to its biocompatibility and mechanical properties.

Keywords:

biomaterials chitosan cytotoxicity fumaric polymers swelling

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Area of Science:

Polymer Chemistry
Biomaterials Science
Regenerative Medicine

Background:

Development of novel biomaterials is crucial for advancing regenerative medicine.
Copolymer synthesis offers tunable properties for specific biomedical applications.
Chitosan is a natural polymer with inherent biocompatibility, often used in tissue engineering.

Purpose of the Study:

To synthesize and characterize a novel terpolymer (FVH) from specific monomers.
To design and evaluate membranes using the synthesized terpolymer for biomedical use.
To assess the physicochemical and biological properties of the terpolymer-chitosan composite for potential applications.

Main Methods:

Terpolymer synthesis via thermal radical polymerization of diisopropyl fumarate (F), vinyl benzoate (V), and 2-hydroxyethyl methacrylate (H).
Characterization using FTIR, 1H-NMR, and SEC.
Membrane fabrication by solvent casting and analysis via SEM, swelling tests, and mechanical property evaluation.
Cytotoxicity and biocompatibility assessment using RAW 264.7 cells and bone marrow mesenchymal progenitor cells (BMPC).

Main Results:

The optimal terpolymer ratio F:V:H was determined to be 5:4:1.
The terpolymer efficiently interacted with chitosan via borax cross-linking, forming scaffolds.
SEM, swelling, and mechanical tests indicated suitable properties for membranes.
Preliminary cytotoxicity and biocompatibility studies showed promising results for the biomaterial.

Conclusions:

The synthesized terpolymer (FVH) and its combination with chitosan represent a viable strategy for creating advanced biomaterials.
These materials demonstrate potential for applications in regenerative medicine.
The approach can be extended to other structurally related polymer systems.