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Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization
M Leticia Bravi Costantino1, Tamara G Oberti1, Ana M Cortizo2
1Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata - CONICET CCT-La Plata, CC 16 Sucursal 4, 1900, La Plata, Argentina.
Journal of Biomedical Materials Research. Part A
|October 26, 2018
Summary
New fumaric copolymers were synthesized and characterized for tissue engineering. DIPF-NIPAM matrices showed improved cell growth and potential for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Tissue Engineering
Background:
- Fumaric copolymers offer tunable properties for advanced applications.
- Understanding the structure-property relationship is crucial for biomaterial development.
Purpose of the Study:
- To synthesize and characterize novel fumaric copolymers with varying architectures.
- To investigate the impact of structural differences on physicochemical and biological behavior.
- To evaluate the potential of these copolymers as matrices for tissue engineering.
Main Methods:
- Conventional radical and RAFT polymerization techniques were employed.
- Copolymers were characterized using FTIR, 1H-NMR, TGA, and SEM.
- Cytotoxicity and cell growth assays were performed on macrophage models.
Main Results:
- Lineal and star architectures were successfully obtained.
- SEM revealed distinct surface morphologies: rough for OEGMA, smooth for DIPF-NIPAM.
- DIPF-NIPAM matrices exhibited no cytotoxicity and enhanced cell growth.
Conclusions:
- Structural variations significantly influence copolymer properties.
- DIPF-NIPAM copolymers demonstrate excellent biocompatibility and cell interaction.
- These materials show promise as scaffolds for tissue engineering applications.
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