Related Experiment Video
Updated: Oct 24, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
[The toxicological testing in the emergency room in the era of choosing wisely]
Kaltrina Haxhimeri1, Majd Ramlawi1
1Service des urgences, Hôpital de La Tour, 1217 Meyrin.
Abstract:
The emergency physician is frequently called upon to take care of intoxicated patients. The identification of the culprit is a diagnostic challenge when the clinical picture is discordant, or the poisoning uncertain. Toxicological screening is of limited usefulness to the ED physician. Results from indiscriminate use can be misleading. The « all-out » search for toxins is expensive and rarely influences the treatment strategy. In the era of the « choosing wisely » campaign, a pragmatic and thoughtful use of toxicological testing is justified.
More Related Videos
09:01A High-throughput Assay for the Prediction of Chemical Toxicity by Automated Phenotypic Profiling of Caenorhabditis elegans
Published on: March 14, 2019
14:20High Throughput SiRNA Screening for Chloropicrin and Hydrogen Fluoride-Induced Cornea Epithelial Cell Injury
Published on: June 16, 2018
Related Concept Videos
Drug Regulation
Prevention of Further Absorption of Poison
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Factors Affecting Drug Response: Overview