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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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[What do we Mean by "Ideal" Blood Pressure Control?]

O D Ostroumova1, A I Kochetkov2, N A Arablincky3

  • 1Russian Medical Academy of Continuous Professional Education, Moscow; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow.

Kardiologiia
|August 16, 2021
PubMed

Insights

High blood pressure variability (BPV) is a significant risk factor for cardiovascular issues. The fixed-dose combination amlodipine/perindopril effectively reduces BPV and blood pressure, improving patient prognosis.

Area of Science:

  • Cardiology
  • Hypertension Management

Background:

  • Arterial hypertension (AH) is a major risk factor for severe cardiovascular and cerebrovascular diseases.
  • Increased blood pressure variability (BPV) is recognized as a novel, independent risk factor for these complications.

Purpose of the Study:

  • To evaluate the efficacy of fixed-dose combination (FC) amlodipine/perindopril in reducing blood pressure and BPV.
  • To assess the clinical significance of managing BPV in patients with AH.

Main Methods:

  • Review of clinical studies and real-life data on amlodipine/perindopril FC.
  • Analysis of BPV reduction across different timescales (visit-to-visit, day-to-day, 24-hour).

Main Results:

  • Amlodipine/perindopril FC demonstrated significant reductions in all measured types of BPV.
  • The combination therapy showed high antihypertensive efficacy in real-world clinical practice.
  • Evidence supports the benefit of reducing BPV for improved patient outcomes.

Conclusions:

  • Fixed-dose combination amlodipine/perindopril is a first-line treatment option for AH.
  • This FC offers a dual benefit of lowering blood pressure and decreasing BPV.
  • Amlodipine/perindopril FC is recommended for a wide range of AH patients to enhance prognosis.

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